Recombinant Human TIGIT
TIGIT (T cell immunoreceptor with Ig and ITIM domains) is an immune checkpoint protein expressed on T cells and natural killer (NK) cells. It functions as an inhibitory receptor that regulates immune responses by binding to ligands such as CD155 (PVR) and CD112 on antigen-presenting cells and tumor cells. Through intracellular ITIM and ITT-like motifs, TIGIT dampens T cell activation, reduces cytokine production, and limits cytotoxic activity. By maintaining immune homeostasis, TIGIT helps prevent excessive inflammation, but its overexpression in cancer can contribute to immune evasion, making it an important target in immunotherapy research.
